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Available online at: (Accessed October 6, 2025)

PMID: 35125818 | doi:10.3748/wjg.v28.i1.23

The study established that FOXO4 maintains senescent cell viability by targeting p53 to the nucleus and preventing apoptosis, and that disrupting the FOXO4-p53 interaction with FOXO4-DRI causes p53 nuclear exclusion and cell-intrinsic apoptosis in ionising radiation-induced and doxorubicin-induced senescent IMR90 fibroblasts

Understanding what are peptides and how they degrade helps you appreciate why proper technique preserves every microgram of active compound in your vial

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