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The biggest known risks are retatrutide-driven GI side effects (nausea 38-43%, diarrhea 33-35%) and dysesthesia - an unusual skin tingling or burning sensation at higher doses

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The SURPASS-4 clinical trials concluded that In people with type 2 diabetes and elevated cardiovascular risk, tirzepatide, compared with glargine, demonstrated greater and clinically meaningful HbA1c reduction with a lower incidence of hypoglycemia at week 52. What is Mounjaro (tirzepatide)

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It also soothes redness, inflammation, and discomfort of the skin