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Despite the loss of its insulinotropic effect, the GLP-1 products of DPP-4 catalysis exert other actions, such as suppression of hepatic glucose production and antioxidant activity in the cardiovascular system [14]
Why this matters for drug discovery GLP-1 receptor biology explains why a single class of drugs can lower blood sugar, curb appetite, and protect the heart and kidneys at once
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This can lead to nausea and vomiting, resulting in dehydration and electrolyte imbalances
The condition predominantly affects women , with a female-to-male ratio of approximately 10:1, and typically presents in middle age, though it can occur at any age
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