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Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former

It is constantly used by our body cells to keep them functioning properly and protect them from damage due to free radicals

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Cons of a Systemic Approach: Lower Local Concentration: The peptide is distributed throughout the body, so the concentration reaching the plantar fascia will be lower than with a direct, local injection

Harward SC, Hedrick NG, Hall CE, Parra-Bueno P, Milner TA, Pan E, Laviv T, Hempstead BL et al (2016) Autocrine BDNF-TrkB signalling within a single dendritic spine