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While tirzepatide's cardiovascular outcomes trial (SURPASS-CVOT) is ongoing and cardiovascular benefits are not yet established, the medication has shown favorable effects on multiple cardiometabolic risk factors

2023 Jan-Jun;19(5):297-317

Applied Physiology, Nutrition, and Metabolism , 34 , 907915

Because acute hyperglycemia stimulates the brains glucose-sensing neurons, it may also lessen the central inhibition of further exercise when exhausted ( 3.4 Mechanism 3.4.1 Insulin signaling pathways and exercise For insulin signaling to occur within insulin-sensitive tissues, the hormone must bind to a specific membrane receptor known as the insulin receptor, which is composed of four subunits: two extracellular -subunits and two transmembrane -subunits

However, damage to this barriersometimes referred to as intestinal permeability or leaky gutcan allow inflammatory compounds such as bacterial endotoxins to enter the bloodstream