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A Randomized Trial Investigating the Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Semaglutide Once-Weekly in Healthy Male Japanese and Caucasian Subject

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The lack of statistically significant reduction in infarct volume, despite a numerical decrease, suggests that DSIPs primary benefit in this model might be more related to functional neurorecovery and neural network plasticity rather than a direct, massive reduction of necrotic tissue [1]

For a minority, persistent symptoms require a dose pause or alternative therapy, and that decision should rest with the clinician and patient