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Summary: Both methylcobalamin and cyanocobalamin effectively treat B12 deficiency, with cyanocobalamin being more stable and cost-effective whilst methylcobalamin is bioactive without requiring conversion

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However, 3-KO mice failed to show any significant changes in body weight following treatment with AOD9604 or hGH

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Strength of evidence: Anecdotal reports, rodent studies, and Phase 2 human trials all carry different weight