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In clinical studies, while the direct effects on -synuclein aggregation in humans are still being investigated, improvements in motor function, cognitive abilities, and general neuronal health have been observed, suggesting that GLP-1 RAs are impacting these pathological processes
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The upstream vs
That is plausible in the context of small effects seen in human studies: Lcarnitine can add a modest nudge when combined with consistent training and sensible eating
It is worth noting that DMF neither affected the antitumor activity in C26, HCT116, MKN45, and MIA PaCa-2 cancer cell lines nor exacerbated the potential effects (e.g., body weight loss or bone marrow suppression) in C26-bearing mice (Miyagi et al., 2019)
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