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Regulation of the Pentose Phosphate Pathway The major regulator of the PPP is the cellular response to oxidative stress

Glutathione is a tripeptide produced naturally by the liver from three amino acids: cysteine, glycine, and glutamic acid

Abbreviations AAS: Antibiotic antimycotic solution -GST: Alpha-glutathione s-transferase ALT: Alanine aminotransferase ASGPR1: Asialoglycoprotein receptor 1 CD206: Mannose receptor CD32b: Fc fragment of IgG receptor IIb CYP3A4: Cytochrome P450 3A4 DILI: Drug-induced liver injury DMSO: Dimethyl sulfoxide IL: Interleukin KCs: Kupffer cells LDH: Lactate dehydrogenase LPS: Lipopolysaccharide LSECs: Liver sinusoidal endothelial cells LVX: Levofloxacin mBCI: Monochlorobimane MDMs: Monocyte-derived macrophages PBS: Phosphate buffered saline ROS: Reactive oxygen species RT: Room temperature TNF-: Tumor necrosis factor-alpha TVX: Trovafloxacin VPM: Vascular perfusion medium References Stevens, J

In certain contexts, H 2 S may interfere with the normal functioning of microglial cells, potentially impairing their reparative functions

Glutathione is evaluated in laboratory research to study redox balance and oxidative stress pathway research