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Tolerability and side effects : Common adverse effects include nausea, vomiting, diarrhoea, and constipation, which typically improve over time

However, there are a few exceptions

Patients should also disclose all medications and supplements currently being taken, including prescription, over-the-counter drugs, vitamins, and herbal remedies, to avoid unexpected interactions and optimize therapeutic efficacy

Some people may experience mild stomach discomfort, nausea, bloating, headache, or allergic reactions

Tirzepatide to semaglutide If you need to move from tirzepatide to semaglutide for any reason, the tirzepatide to semaglutide conversion chart provides the reverse calculations