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Conversely, nicotine may exert paradoxical inhibitory effects by activating immune pathways and inducing apoptosis, such as through stimulation of immature dendritic cells via PI3K/Akt signaling and modulation of caspase-3 and Cyclin B1 expression through 7-nAChR signaling [36]

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Starting with doses is crucial, and we should closely observe the effectiveness and tolerability of the treatment while adjusting the dosage as necessary

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P = 0.0004) compared to placebo, without increasing time spent in hypoglycemia (Supplementary Table 12)