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Gastrointestinal distress, such as nausea and abdominal discomfort, can occur as a response to the chemical composition of glutathione or its effect on the stomach lining
However, a retrospective cohort study published in Diabetes Care did find that use of GLP-1 medications for 1-3 years was associated with a slightly increased risk of all thyroid cancer (adjusted hazard ratio 1.58) and medullary thyroid cancer specifically (adjusted hazard ratio 1.78)
Moreover, they generate most of the chemical energy (e.g., through the citric acid cycle and the electron transport chain) needed to power the cells biochemical reactions and, thereby, they are a source for free radicals
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