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Similarly, no group separation was found in the liver, with only 20 proteins induced by GLP-1GIPLani and 17 induced by GLP-1GIP (out of which 16 overlapped), and no clear pathway enrichment (Extended Data Fig

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Understanding these mechanisms is essential for appreciating the therapeutic potential of GLP-1 and GIP agonists in obesity management: These insights into GLP-1 and GIP's roles in weight management underscore the significance of dual agonists in offering a novel approach to combat obesity and diabetes, with tirzepatide exemplifying the therapeutic promise of this strategy [1] [2] [7] [8] [9] [11]

van Raalte DH, Bjornstad P, Cherney DZI, de Boer IH, Fioretto P, Gordin D, Persson F, Rosas SE, Rossing P, Schaub JA, et al

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