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Hydroxocobalamin is characterised by extended tissue retention

Localized dermal regeneration studies use 500mcg to 1mg administered subcutaneously every 48 hours, anti-inflammatory models use 200mcg to 500mcg daily or every other day, and systemic collagen synthesis protocols use 1mg to 2mg every 72 hours for multi-week studies

These reports feed into the safety database that the FDA uses to evaluate whether a compounded substance warrants additional restrictions

Still, animal products may also contain other substances that can interfere with vitamin B12 absorption, so vegetarians and vegans may be at risk of deficiency

The liver is the main organ for vitamin B12 storage