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"It means that FDA has identified a potential safety issue, but it does not mean that FDA has identified a causal relationship between the drug and the listed risk." People who use these medications and have questions or concerns about side effects should speak with their health care provider, the FDA says

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A 2025 study reported evidence of telomere length stabilization or modest lengthening, raising the possibility that metabolic therapies may influence pathways related to genomic stability and replicative lifespan [16]

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