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In another observational study of patients aged 40 years with T2D, body mass index 25 kg/m 2 , and pre-existing ischemic heart disease, tirzepatide was associated with a lower rate of the primary composite outcome of all-cause mortality, myocardial infarction, and ischemic stroke (HR 0.60, 95% CI 0.430.84), as well as reductions in all individual components of the composite outcome [29]

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