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How This Works IGF-1 LR3 is a synthetic analog of human insulin-like growth factor-1 engineered with an N-terminal extension (13 amino acids) and a glutamic acid substitution at position 3, resulting in significantly reduced binding affinity to IGF binding proteins [1]

The primary endpoints are improvements in body weight, waist circumference, and BMI measured in metric units to publish results across the world in a clear and comparable manner

Rather than focusing on weight alone, he also tracks visceral fat, muscle mass, and overall body composition using DEXA scans where available and body composition scales for ongoing home monitoring

Lu Y, Tonissen KF, Di Trapani G

Announces Phase 2 Success of NA-931: an Oral Quadruple Receptor Agonist for Obesity at EASD 2025 Dr