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Long-term risks include: gallstones chronic gallbladder inflammation need for gallbladder removal (cholecystectomy) recurrent biliary pain Thyroid Tumor Risk (Black Box Warning) Several GLP-1 drugs carry an FDA boxed warning for thyroid C-cell tumors and Medullary Thyroid Carcinoma (MTC), based on long-term rodent studies
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Cells were treated as described above for 24 h
while, on the other hand, the excessive release of mitochondrial reactive oxygen species (mtROS) degrades tight junction proteins and the basement membrane by activating matrix metalloproteinases (MMPs) and inflammatory signaling pathways
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