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Important safety considerations include the risk of pancreatitis (all GLP-1 agonists carry warnings about this), gallbladder disease (more common with greater weight loss), and a caution with semaglutide in patients with pre-existing diabetic retinopathy, where rapid improvement in glucose control may temporarily worsen retinopathy
doi: 10.3892/ijmm.2024.5420 77 YiPZhangRQinZZhaoXWuCYuYet al
Kelly A et al
If side effects worsen after switching to split dosing, it may indicate a measurement error resulting in inadvertently higher individual doses, or it may suggest that your side effects are not primarily driven by peak concentration
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