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The radioprotection studies of DHS were carried out in a mice model wherein intraperitoneal administration of DHS (2 mg/kg body weight for five consecutive days before irradiation and three times per week during the post-irradiation period) showed significant improvement in the 30-day survival against the lethal dose (8 Gy, -rays) of WBI (Table 2) [64]

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Alternatively, the suppression of the lipid flippase solute carrier family 47 member 1 (SLC47A1) enhances ferroptosis by favoring the ACSL4sterol O-acyltransferase 1 (SOAT1) pathway over the ACSL4LPCAT3 pathway, leading to the production of PUFA cholesterol esters in pancreatic cancer cells [102]

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2 Time-effect curve of the formalin test

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de la Monte SM, Re E, Longato L, Tong M

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