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On June 24, 2026, Novo Nordisk, a global leader in diabetes and obesity treatments, officially launched its flagship weight-loss drug Wegovy (Semaglutide) in India

Indeed, the pharmacokinetic and pharmacodynamics of any drug taken by mouth should be appraised considering the role of the microbiota, as the varied efficacy of some chemotherapeutics such as 5-FU has been proven to directly depend on this host-microbiota metabolism (400)

For example, unfavorable FTO or MC4R variants may indicate need for higher doses or adjunctive strategies

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The clinical relevance of lymphatic and blood-vessel invasion in breast-cancer patients