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Published research consistently shows greater body fat reduction in CGM users compared to diet alone

Hepatic Fat Reduction Data In the retatrutide phase 2 trial, MRI-PDFF-measured hepatic fat fraction fell from a mean of 15.2% at baseline to 3.0% at 48 weeks in the 12 mg group, a relative reduction of 81.1%

The underlying mechanism is TD-induced impairment of PDHC activity, which causes remodeling of glucose metabolism in the macrophages

Each compound was also incubated in the absence of pancreatin (8.3 L of the oligomer stock solution was diluted with 190 L of TRIS 10 mM pH 7.5)