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These effects usually subside as the body adjusts to the medication
Patients with certain genetic profiles may experience faster adaptation, while others benefit from slower, more gradual dose increases to minimize side effects while maintaining weight loss results
According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant
