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Rats were subjected to middle cerebral artery occlusion (MCAO) for 2 h followed by reperfusion
The dose-response curve in clinical trials was clean and linear
Nature 364 (6438), 626632
Results at 72 weeks: Placebo: 3.1% weight loss Tirzepatide 5 mg: 16.0% weight loss (35.3 pounds average) Tirzepatide 10 mg: 21.4% weight loss (49.7 pounds average) Tirzepatide 15 mg: 22.5% weight loss (52.3 pounds average) The percentage of participants achieving 5% or more weight loss was 89% (5 mg), 96% (10 mg), and 96% (15 mg)
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