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ACS Chem Neurosci 16:818825 Dickson SL, Shirazi RH, Hansson C et al (2012) The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors
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In the new trial, published in The Lancet on Thursday, patients on 7 to 14 milligrams of Rybelsus lost, on average, between 8 and 11 pounds, while patients on 12 to 36 milligrams of orforglipron lost an average of 15 to 20 pounds, roughly the same level of weight loss that people with diabetes tend to achieve when taking Ozempic
In clinical trials, semaglutide produced average total body weight loss of roughly 15% (STEP program), while tirzepatide produced average reductions in the range of about 1521% (SURMOUNT program)
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