2.2 GIPR agonism serves to reduce GLP-1R mediated GI AEs in the clinic Treatment with GLP-1R agonists can drive nausea, diarrhea, vomiting, and constipation, which often results in discontinuation of treatment (6-10% of patients) or reduction in dose (~15% of patients) (63)
The FDA approves at 27 with comorbidities
Persistent or recurrent infections may indicate antibiotic resistance, inadequate treatment duration, or underlying urological abnormalities requiring further investigation with imaging studies or urology referral
Preclinical investigations suggest that combining these two peptides may amplify certain laboratory endpoints beyond what is observed when either compound is examined independently
Duranay M, Akay H, Yilmaz FM, et al