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By competing with acetylated histones for binding to BET proteins, BET inhibitors reduce oncogene expression, thereby inhibiting tumor cell proliferation and promoting apoptosis (Shi et al., 2014)
Its weight loss effects are likely due to several combined actions, including appetite reduction, increased fullness, glucose regulation and changes in energy balance
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Via this metabolic adaptation, cells can continually generate TCA metabolites, such as -KG and citrate, which are converted to cytosolic acetyl-CoA for lipid biosynthesis (Fig
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