About the Experts Caroline Messer, M.D., is an endocrinologist with board certification in internal medicine, diabetes, and metabolism
After reaching your weight loss goals, Semaglutide may be used in lower doses to help maintain your weight, along with continued healthy habits
Before Retatrutide, no pharmaceutical weight loss treatment had ever produced average results exceeding 21% in clinical trials
This targeted mechanism helps increase growth hormones without significantly affecting other hormones like cortisol or prolactin, reducing unwanted side effects
In March 2026, topline results from the TRANSCEND-T2D-1 trials showed that participants with Type 2 diabetes achieved an average A1C reduction of up to 2.0% and lost nearly 17% of their body weight over 40 weeks