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But its GI side effect profile is also the most aggressive, with nausea rates reaching 40% to 50% and vomiting rates significantly higher than cagrilintide monotherapy

(PubMed) Stanley CA

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Since obesity is associated with an increased risk of cardiovascular disease, the ongoing SELECT study is investigating whether once-weekly semaglutide 2.4 mg will reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease [61]

Constipation can also occur, though its less likely with good hydration and fiber intake