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K.MllerH.-M.Botella-MunozJ.et al (2001)
A small, but growing number of MDs
Common gastrointestinal side effects include: Nausea the most frequently reported side effect, particularly during dose escalation Vomiting often linked to nausea and typically dose-dependent Diarrhoea and constipation both have been reported, reflecting altered gut motility Decreased appetite a desired therapeutic effect, but one that requires monitoring to ensure adequate nutrition Severe or prolonged vomiting and diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)
The breakthrough came when researchers discovered that combining glucagon receptor activation with GLP-1 activity redirects the effects toward increased calorie burning rather than hyperglycemia
Slivka, A
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