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IF also improves the bioavailability of nitric oxide, which is an essential factor for controlling vascular tone, decreasing arterial stiffness, and preventing endothelial dysfunction [68, 73]
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They investigated the mechanism of action of these phytocannabinoids and found that, among five studied compounds, two were sodium channel blockers and had an almost similar mechanism of action as CBD (Milligan et al., 2023)
However, a deeper understanding of the complex nature of BBB and BCB together with the development of the new models and the improvement of the current barrier-modeling techniques indicates that they may become a very useful research tool for studying BBB and BCB in the future
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