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Additionally, protein post-translational glycosylation-mediated association between the levels of von Willebrand factor (vWF) and ABO blood groups has been established [52]

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Activation of TGR5 in the brain reduces neuroinflammation by inhibiting pro-inflammatory cytokines and enhancing BDNF-mediated synaptic resilience, whereas disturbances in BA metabolism in IBDcharacterized by a reduction in secondary BAsare linked to increased anxiety risk and visceral hypersensitivity (Zhao et al., 2025)

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