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These medications promote weight loss by: Suppressing appetite: GLP-1 medications act on the brains hypothalamus to reduce hunger signals, helping individuals reduce cravings and eat fewer calories
The problem, however, was that the molecules half-life was much too short to serve as a useful medicine
Wei T, Thakur SS, Liu M
(40, 41) Since the mechanism of semaglutide in weight control was primarily appetite restriction and reduction of food intake, there might be some variations on its effectiveness among people with different causes of obesity (42, 43)
Electrolyte imbalance from GLP-1 agonists
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