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Its structure allows it to bind to and activate three key receptors: GLP-1 receptor agonism: Reduces appetite, slows gastric emptying, and improves insulin secretion in response to glucose

This could partly be explained by the fact that HbA1c reflects long-term overall glycemic control and may not accurately capture glucose variability, including postprandial hyperglycemia and hypoglycemia [19]

doi:10.1101/cshperspect.a009183 Acknowledgments This work was supported by the Chang Gung Memorial Hospital [Grants CMRPD1A0531, CMRPD1C0231, CMRPG391311, CMRPG3A1131] and the Ministry of Science and Technology, Taiwan [Grant NMRPD181001-3]

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Injectable administration bypasses this variability and may provide more consistent availability