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Gallbladder disease: Rapid weight loss can predispose to gallstones, and some trials (particularly with high-dose semaglutide and liraglutide for obesity) noted a slight increase in gallstone-related events

GLP-1 medications help quiet that constant food noise. They allow the brain to properly receive fullness and satisfaction signals again

Similar to GLP-1, GIP is an intestinally secreted peptide that promotes insulin biosynthesis and islet -cell differentiation and reduces apoptosis

Severe, persistent nausea that doesn't ease after the first couple of weeks at a stable dose is worth discussing with your provider

The cumulative effects build over time