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A recent survey conducted by Tebra, a health research firm, found that out of 640 GLP-1 users, 36% reported microdosing the medication
Some clinicians have adopted this reasoning and prescribe both medications off-label, particularly phentermine combined with semaglutide or phentermine combined with tirzepatide
5 Mechanistically, exercise-induced interleukin-6 (IL-6) appears to stimulate GLP-1 secretion from intestinal L-cells and pancreatic -cells in experimental models, which may contribute to improved appetite regulation and insulin secretion during and after exercise
Although some emerging research suggests that GLP-1RAs might reduce binge-eating episodes, there is not yet enough evidence to support their use specifically for treating binge-eating disorder (BED) and its associated psychopathology