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From a development chemists perspective, Melanotan II is the more pharmacologically noisy molecule: it delivers more signal per milligram, but much of that signal is not targeted at tanning alone, elevating the risk of off-target or unanticipated effects
There is a general agreement that the neural crest is the origin of MNTI for the following reasons: i) The tumor cells are similar to neuroblasts with respect to histological evaluation
10.1210/jc.81.9.3312
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ALC was generally well tolerated, with predominantly mild gastrointestinal or central nervous system adverse events and no excess of serious harms compared with controls
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