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Retinol is a reasonable starting point for most

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Eli Lilly cannot submit the NDA until enough Phase 3 data is available to demonstrate both efficacy and safety across the intended patient populations

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Studies have observed decreased cyclooxygenase-2 (COX-2) gene expression, reduced myeloperoxidase activity, and lower levels of pro-inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-)