As of June 2026, tesamorelin is FDA-approved only for HIV-associated lipodystrophy (sold as EGRIFTA WR and EGRIFTA SV), ipamorelin is not FDA-approved, and the blend is not FDA-approved
The selectivity data are primarily from Raun et al.'s rat work
69 Crucially, these effects happen at doses which are inside the normal physiological range for circulating endogenous ghrelin
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The reason I started taking AG1 way back in 2012, and the reason why I still continue to take it every single day, is because AG1 is, to my knowledge, the highest quality and most comprehensive of the foundational nutritional supplements on the market