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Main Phase (Baseline to Week 26): Study 1 This study randomized 412 HIV-infected patients with lipodystrophy and excess abdominal fat to receive either tesamorelin (N=273) or placebo (N=137)
Clinical Monitoring Guidelines Regular monitoring helps maximize therapeutic benefit while minimizing risk
Most are mild and get better over time
The gradual onset allows the body to adapt to the medication whilst minimising adverse effects, particularly gastrointestinal symptoms that can occur with rapid dose escalation
Then, 6-phosphogluconate dehydrogenase (PGD) that often functions as a homodimer catalyzes the oxidative decarboxylation of 6-phosphogluconate (6-PG) to synthesize ribulose-5-phosphate (Ru5P) and a second NADPH in the third reaction
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