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Studies have demonstrated that ranolazine protects against doxorubicin-induced oxidative stress and cardiac dysfunction by inhibiting late sodium current and reducing reactive oxygen species production [145]

Moreover, MATE1, driven by the secretion of cationic drugs with opposite H + -gradients, is involved in the efflux of Pt drugs as well as other endogenous or exogenous organic cations in the DRG (Fujita et al., 2019)

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This could make the drug less effective for managing blood sugar and weight