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MS and MS/MS data were collected by a Q-TOF mass spectrometer operating in the positive ESI mode

These findings suggest that GLP-1 therapies may target both reward-seeking and stress-driven addiction behaviors, but the review emphasized that stress-system effects are complex and not yet fully understood

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Statistical methods Participants demographic data were summarized with descriptive statistics (mean and standard deviation for continuous variables, number and percent for categorical variables)

Putting the Numbers in Perspective The 3.3 percentage point difference between Retatrutide (24.2%) and Zepbound (20.9%) may seem modest in percentage terms, but translates to meaningful real-world differences