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MDM2-MDM4 RING inhibitors (MMRi) such as MMRi62 and MMRi71, which were initially designed to inhibit the MDM2MDM4 interaction to stabilize p53 [137], have recently been demonstrated to trigger the death of cancer cells

However, phase 1 clinical trials in patients with locally advanced non-small cell lung cancer and pancreatic cancer showed suboptimal compliance with the diet, indicating challenges in practical application

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After 40, both weaken at the same time

It is especially important for the regular operation of dysfunctional mitochondria, helping to remove toxins and playing a vital role in energy production and expenditure in cells