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in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )
Int J Obes Relat Metab Disord
This exercise-responsive pattern led researchers to propose MOTS-c as a mitokine, a signaling molecule released by the mitochondria during physical exertion that mediates some of the systemic benefits of exercise
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