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The Specialist Pharmacy Service (SPS) and NHS practice guidance advise that when a GLP-1 receptor agonist is introduced, any DPP-4 inhibitor should generally be discontinued due to the mechanistic overlap and lack of additive benefit

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SS again followed the same pattern as GLP-1, where we found a correlation between SS and GLP-1 secretion, R 2 = 0.89 (Supplemental Figure 1B), and the increase in SS output was significantly higher when SSTR5a was combined with luminal glucose compared with glucose administration alone (luminal glucose, 28 6 fmol/min vs