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Clinical trials have shown that GLP-1R agonists increase microvascular blood volume and flow in cardiac muscle, and these effects are preserved in obese individuals with vascular insulin resistance
How they work: Provide direct fuel for muscles, stimulate muscle protein synthesis, and reduce muscle breakdown
& Nedergaard, M
The abnormal release of Ca 2+ from the mitochondria to the cytosol leads to the activation of microglia, neuroinflammation, and finally, cell death [29, 93]
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W., & Ryan, D
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