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What is the future of GLP-1 and GIP receptor agonists

Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al

The convenience of alternative routes must be weighed against potentially reduced efficacy

A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structures