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Adverse events and change in disease activity is evaluated

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These Include: It may predispose women to bone fractures (especially at the hip) Chronic insomnia Chronic anxiety Some individuals may develop a chronic caffeine headache Depression Digestive issues It may cause high blood pressure or aggravate already existing high blood pressure It may be linked to miscarriages and low birth weight in infants Tolerance Dependence Withdrawal symptoms Caffeine Allergy Most individuals can safely consume as much as 400mg of the stimulant without caffeine adverse effects

RBD, receptorbinding domain