GLP1-RAs, developed to treat diabetes and obesity, have shown hepatoprotective and anti-inflammatory effects in preclinical models of AH [128-131]
Saturation and diminishing returns: Beyond certain dose, additional peptide provides minimal incremental benefit as receptors become saturated or downstream pathways maximally activated
Some people may struggle to absorb enough through food or supplements, making injections a helpful option
The addition of B12 does not boost weight loss, but may help combat the side effects of semaglutide, such as lethargy and dizziness, by promoting metabolism and increasing the availability of usable energy
Although it cannot yet be determined whether vitamin B 12 deficiency plays a causal role in depression, it may be beneficial to screen for vitamin B 12 deficiency in older individuals as part of a medical evaluation for depression