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Methylmalonic acid and homocysteine levels can help confirm B12 deficiency when serum levels are borderline
The administration is non-invasive and requires no injections, medical devices, or surgical tools
Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)
Long-term deficiency can lead to irreversible nerve damage, dementia, and other neurological issues
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